Quick Answer: Tirzepatide must be kept refrigerated between
Tirzepatide is an innovative treatment for adults with type 2 diabetes and for weight management. Manufactured by the American pharmaceutical company Eli Lilly, it is available in the UK under the name Mounjaro. While another tirzepatide medication is available in the USA under the name Zepbound, it is currently not available in the UK.
As prescriptions for tirzepatide increase in the UK and new drugs' approval may come soon, it’s crucial to understand its specific storage requirements.
Whether in vials, syringes, or injection pens, tirzepatide is highly sensitive to temperature fluctuations. It must be refrigerated before use and can only stay outside the fridge for a limited period under strict conditions.
In this guide, we’ll answer all your key questions about storing Mounjaro, Zepbound, and compounded tirzepatide, including:
- Why does tirzepatide need refrigeration?
- What happens if it’s not refrigerated?
- How long can tirzepatide stay out of the fridge?
- How do you safely store it at room temperature?
- How long does tirzepatide last?
- Can you freeze it?
- What should you do if your tirzepatide gets warm?
- And much more!
Does Tirzepatide Need to Be Refrigerated?
Yes, tirzepatide must be refrigerated. All forms of tirzepatide, including Mounjaro, Zepbound (sold in the USA) and compounded versions, need to be kept in a fridge immediately after purchase and before use. Proper refrigeration ensures the medication remains effective.
Storing Tirzepatide
According to Eli Lilly, the manufacturer of both Zepbound and Mounjaro, tirzepatide should be stored in a refrigerator at temperatures between 2°C and 8°C. It must also be kept in its original carton to shield it from light exposure.
Mounjaro, sold in the UK for both weight-loss and diabetes, can be kept out of the fridge for up to 30 days, provided it is not exposed to temperatures exceeding 30°C. But its American version can only stay 21 days at room temperature.
Regarding Zepbound (only available in the USA as of today), it can stay unrefrigerated for up to 21 days.
For compounded tirzepatide, refrigeration is also required. However, the specific storage conditions may vary, so it’s always a good idea to refer to the instructions provided by your pharmacy.
Related article: Does Mounjaro Need to Be Refrigerated? How to Store Your Pens
How Long Does Tirzepatide Last in the Fridge?
When stored in a refrigerator, tirzepatide injections such as Mounjaro and Zepbound typically remain effective for several months. The manufacturer’s expiration date, usually printed on the packaging, indicates how long the medication will stay effective under proper refrigeration, often up to a year.
Compounded tirzepatide, on the other hand, may have a shorter shelf life, so it’s important to check the packaging or confirm with the compounding pharmacy for the exact expiration details.
What If Tirzepatide Is Not Refrigerated?
Whether it's sold under the name Mounjaro or Zepbound, Tirzepatide is a biological drug that requires refrigeration to maintain its delicate molecular structure. Without proper refrigeration, the peptide begins to break down, significantly reducing its effectiveness.
If tirzepatide is left unrefrigerated for longer than recommended, the degradation process compromises its potency, making it less effective for managing diabetes or supporting weight loss.
To prevent any issues, always ensure your fridge is working properly and set to the correct temperature of 2°C to 8°C.
Related article: How to Travel with Mounjaro: Safety Tips & Travel Cases
How Long Can Tirzepatide Be Out of the Fridge?
Mounjaro as sold in the UK can be kept out of the fridge for up to 30 days.
Mounjaro and Zepbound as sold in the USA can be kept out of refrigeration for up to 21 days.
However, compounded tirzepatide may have different requirements, so always verify with your pharmacy. Remember to note the date you take the medication out of the fridge to track how long it has been unrefrigerated.
Storing Tirzepatide at Room Temperature
If storing tirzepatide at room temperature, certain precautions must be taken:
- Ensure the ambient temperature does not exceed 30°C.
- Protect it from direct light by keeping it in its original packaging.
- Store it in a cool, shaded location away from heat sources such as ovens or radiators.
If you are travelling or expecting high temperatures, consider using a medical cooler to protect your medication.
Can You Put Tirzepatide Back in the Fridge?
Once tirzepatide has been stored at room temperature, it should not be returned to the refrigerator. This applies to both Mounjaro and Zepbound. Always plan storage carefully to avoid waste.
What Happens if Tirzepatide Gets Warm?
Exposing tirzepatide to temperatures above 30°C can cause it to degrade rapidly, reducing its effectiveness. If this happens, it’s best to discard the medication and use a new one.
Can Tirzepatide Be Frozen?
No, freezing tirzepatide damages its structure, rendering it ineffective. Avoid placing it near your fridge’s freezer compartment or using ice directly when transporting it.
We'd Love to Hear Your Thoughts!
Have you been prescribed Tirzepatide in the UK or USA? Do you find its storage requirements to be challenging? Or do you have any tips or questions you want to share with us?
