Quick Answer: Testosterone injections generally don’t need refrigeration; they should be stored at room temperature (20°C to 25°C) and protected from heat or freezing to remain effective.
There’s a common misconception that testosterone needs to be refrigerated. Let’s clear up this myth and take a closer look at the proper storage practices and guidelines for testosterone vials sold in the UK.
Related article: Travelling with Testosterone: Travel Cases, TSA Regulations, Tips!
What is testosterone?
Testosterone is a naturally occurring hormone in the human body. While present in both men and women, it plays a vital role in men’s health, contributing to:
- Development of the penis and testes
- Muscle and bone strength
- Sex drive and sperm production
- Growth of facial and pubic hair
- Red blood cell production
- And other important functions
Low testosterone levels (low T) in men can result in symptoms like reduced energy, a decline in libido, mood swings, weight gain, fertility issues, and weakened bones. For women, low testosterone may lead to decreased sex drive, weakened bone strength, and, in some cases, mental health challenges such as depression.
When these issues significantly affect quality of life, testosterone therapy may be recommended. This involves administering testosterone injections to restore hormonal balance. Testosterone therapy is also used by transgender men as part of masculinisation treatment.
Four types of testosterone injections
There are several types of testosterone injections available:
- Testosterone cypionate (e.g., Depo-Testosterone)
- Testosterone enanthate (e.g., Xyosted and generic versions)
- Testosterone propionate
- Testosterone undecanoate (e.g., Aveed)
- Combination of testosterone esters
While the hormone itself is the same, these formulations differ in their esters, which affect the hormone’s release rate and help maintain steady testosterone levels. Your doctor will determine the best type for your specific needs.
Testosterone injections are administered intramuscularly. Patients may self-inject at home using a vial and syringe or have it done by a healthcare professional. The frequency varies—it can range from weekly to monthly, depending on the condition and doctor’s prescription.
Testosterone does not need to be refrigerated
If you’ve been prescribed testosterone injections, it’s crucial to store them properly to ensure their effectiveness. Testosterone is a temperature-sensitive medication, so it must be kept away from excessive heat to remain effective. However, in most cases, it does not need to be refrigerated.
How to store testosterone
According to Pfizer, testosterone cypionate does not require refrigeration. It should be stored at room temperature between 20°C and 25°C, away from light and heat sources. This guideline also applies to other testosterone formulations such as testosterone enanthate and undecanoate (Aveed).
Testosterone must be protected from heat
While refrigeration is unnecessary, testosterone vials must not be exposed to temperatures above 25°C.
If you live in a warmer climate or don’t have air conditioning, consider using a medical-grade cooling case, such as those offered by 4AllFamily. These specialised cases keep your injections within a safe temperature range, even in hot weather.
Related article: Tips for Travelling with Medications Internationally
Do not inject refrigerated testosterone
If the ambient temperature exceeds 25°C and you choose to refrigerate testosterone, do not inject it immediately after removing it from the fridge. Cold testosterone and its carrier oil can crystallise, causing discomfort and swelling at the injection site.
Let refrigerated testosterone warm to room temperature for around 30 minutes before use. If you notice cloudiness, particles, or crystals in the vial, wait until the solution clears completely before injecting.
What happens if testosterone gets warm?
Testosterone can degrade when stored above 25°C, potentially losing its efficacy. Additionally, high temperatures may encourage bacterial growth, making the vial unsafe to use. Never use testosterone that has been exposed to excessive heat for an extended period.
What if testosterone freezes?
Freezing testosterone can also damage its chemical structure, making it ineffective and unsafe to use—even if it thaws later. This rule applies to many injectable medications, such as insulin.
How long does a vial of testosterone last?
When stored correctly, testosterone vials typically have a shelf life of 24 to 36 months. Always check the manufacturer’s label for the expiration date, as this can vary depending on the product. Using expired testosterone may result in reduced effectiveness, which could impact the success of your therapy.
Are you undergoing testosterone therapy? What type are you using, and how do you store it at home?
